England manager Eddie Jones has left Henry Slade out of his 36-man squad for the autumn internationals.
Center Slade missed the 2-1 series win in Australia in the summer due to shoulder surgery but has played for Exeter since the start of the season.
Harlequins winger Cadan Murley has been called up to the England squad for the first time for November’s games.
He is one of six players preparing to face Argentina, Japan, New Zealand and South Africa.
The rest consist of Northampton’s Alex Coles and David Ribbans, along with Gloucester’s Georgia-born Val Rapava Ruskin, Newcastle hooker George McGuigan and Saracens second-row Hugh Tizard.
Back row Jack Willis is alone in the cash-strapped Wasps squad.
Sale scrum-half Raffi Quirke is in the squad after returning from injury after making just two appearances this season, making way for Northampton’s Alex Mitchell.
Bristol prop Kyle Sinckler will return after missing the summer trials against the Wallabies with a back problem, but there is no place for Saracens’ Elliot Daly.
“This is a very strong, lively team and some good players have been left out,” Jones said.
“We are delighted with the depth and strength of the squad.
“The Autumn Internationals will be like a mini Rugby World Cup for us, starting with two tough games against Argentina and Japan and mirroring our Pool games in next year’s tournament.
“After that we have knock-out type games against New Zealand and South Africa – the four games will be great tests for us.”
Back: H Arundell (London Irish), J Cokanasiga (Bath), O Farrell (Saracens), G Furbank (Northampton), W Joseph (London Irish), M Malins (Saracens), J May (Gloucester), C Murley (Harlequins), J Nowell (Exeter), G Porter (Leicester), R Quirke (Sale), M Smith (Harlequins), F Steward (Leicester), M Tuilagi (Sale), J van Poortvliet (Leicester), B Youngs (Leicester).
Forwards: A Coles (Northampton), L Cowan-Dickie (Exeter), T Curry (Sale), E Genge (Bristol), J Heyes (Leicester), J Hill (Sale), M Itoje (Saracens), C Lawes (Northampton), L Ludlam (Northampton), G McGuigan (Newcastle), V Rapava-Ruskin (Gloucester), D Ribbans (Northampton), B Rodd (Sale), S Simmonds (Exeter), K Sinckler (Bristol), J Singleton (Gloucester), H Tizard (Saracens), B Vunipola (Saracens), M Vunipola (Saracens), J Willis (Wasps).